Reinhard Lührmann Selected Research

Small Nuclear Ribonucleoproteins (snRNP)

1/2022	Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells.
4/2007	Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.
3/2002	Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.

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Reinhard Lührmann Research Topics

Disease

6	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2022 - 03/2002
2	Neoplasms (Cancer) 01/2019 - 01/2018
2	Retinal Diseases 10/2018 - 01/2014
1	Ciliopathies 01/2021
1	Lung Neoplasms (Lung Cancer) 11/2016
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 10/2004

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2002
3	RNA Precursors (Precursor, mRNA)IBA 01/2022 - 03/2002
3	Small Nuclear Ribonucleoproteins (snRNP)IBA 01/2022 - 03/2002
2	RNA Splicing FactorsIBA 11/2016 - 02/2007
1	pladienolide BIBA 01/2018
1	RNA Helicases (RNA Helicase)IBA 01/2014
1	EnzymesIBA 10/2012
1	GTP Phosphohydrolases (GTPases)IBA 02/2007

Therapy/Procedure

1	Precision Medicine 01/2019